Computational Optimization of DNA Activity (CODA) Paper on BioRxiv

We’re really happy to see that our amazing collaboration with the Tewhey and Sabeti Labs is finally public. Click through to the pre-print or read the co-first author Sager’s tweet-torial below.

Or just check out this completely machine-designed neuronal enhancer that shares no homology to anything thats ever existed in nature, working like a pretty great neuronal enhancer. Our goal was to be able to read regulatory grammar and then write new functions into it, and I think we’ve made a pretty cool start!

I’m excited to share some work I co-lead with @i_rodcast and spanned the labs of @PardisSabeti, @ReillyLikesIt, and @r_tewhey to design and validate synthetic cis-regulatory elements with cell type-specific activity. https://t.co/BqZYaGKwJX 1/n

— Sager Gosai (@SagerGosai) August 10, 2023